This combination of agents is now available as the branded Cyanide Antidote Package or as the generic Cyanide Antidote Kit. Hydroxocobalamin is an antidote that seems to have many of the characteristics of the ideal cyanide antidote: rapid onset of action, neutralizes cyanide without interfering with cellular oxygen use, tolerability and safety profiles conducive to prehospital use, safe for use with smoke-inhalation victims, not harmful when administered to non-poisoned patients, easy to administer. The Lilly Cyanide Antidote Kit was the first and, for many years, the only such kit available it contained amyl nitrite, sodium nitrite, and sodium thiosulfate. Hydroxocobalamin differs from these antidotes in that it has not been associated with clinically significant toxicity in antidotal doses. The potential for serious toxicity limits or prevents the use of the Cyanide Antidote Kit, dicobalt edetate, and 4-dimethylaminophenol in prehospital empiric treatment of suspected cyanide poisoning. Cyanide Kit, Eli Lilly, Indianapolis, IN) contains amyl nitrite, sodium nitrite, and sodium thiosul. 2 Cyanide inhibits oxidative phosphorylation by binding cytochrome a3 (a part of Complex IV of the electron transport chain) 2. Whole blood cyanide level was 13 g/mL approximately one hour after. Cyanide (CN) is a rapidly lethal toxin, producing damage to highly ATP-dependent organs like the brain and heart by inhibiting oxidative phosphorylation, thereby decreasing ATP production. Administration of the Lilly Cyanide Antidote kit (Eli Lilly and Co, Indlanapolis) resulted in prompt resolution of symptoms and full recovery. The data available to date do not suggest obvious differences in efficacy among antidotes, with the exception of a slower onset of action of sodium thiosulfate (administered alone) than of the other antidotes. A 24-year-old woman ingested an unknown amount of potassium cyanide in a suicide attempt. Each of the antidotes shows evidence of efficacy in animal studies and clinical experience. This paper reviews preclinical and clinical data on available cyanide antidotes and considers the profiles of these antidotes relative to properties of a hypothetical ideal cyanide antidote. CYANOKIT (hydroxocobalamin for injection) for intravenous infusion is a cyanide antidote package which contains one colorless 250 mL glass vial, containing 5 g dark red lyophilized hydroxocobalamin, pH adjusted with hydrochloric acid, one transfer spike, one intravenous administration set, one quick use reference guide and one package insert. Critical assessment of cyanide antidotes is needed to aid in therapeutic and administrative decisions that will improve care for victims of cyanide poisoning (particularly poisoning from enclosed-space fire-smoke inhalation), and enhance readiness for cyanide toxic terrorism and other mass-casualty incidents. The international medical community lacks consensus about the antidote or antidotes with the best risk-benefit ratio. However, your healthcare provider may have more information concerning specific programs available in your area.Cyanide has several antidotes, with differing mechanisms of action and diverse toxicological, clinical, and risk-benefit profiles. No Patient Assistance Programs were found for this medication. Patient assistance programs (PAPs) are typically sponsored by pharmaceutical companies and offer cost-free or discounted medicines,Īs well as copay programs, to individuals with low income or those who are uninsured/under-insured and meet specific criteria.Įligibility requirements for each program may vary. Patient Assistance & Copay Programs for Cyanokit No manufacturer promotions could be found for this medication. Target, WalMart Pharmacy, Duane Reade and 65,000 pharmacies nationwide. Valid at all major chains including Walgreens, CVS Pharmacy, Know the uses, side effects, composition, precautions and more about CYANIDE ANTI DOTE MEDICINES KIT INJ. Order CYANIDE ANTI DOTE MEDICINES KIT INJ online and get the medicine delivered within 4 hours at your doorsteps. Note: This is a drug discount program, not an insurance plan. Apollo Pharmacy - Buy CYANIDE ANTI DOTE MEDICINES KIT INJ, null at Rs.16350 in India.

Whole blood cyanide level was 13 micrograms/mL. Over-the-counter drugs and pet prescriptions. Administration of the Lilly Cyanide Antidote kit (Eli Lilly and Co, Indianapolis) resulted in prompt resolution of symptoms and full recovery.

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